The poor oral bioavailability of Ranitidine hydrochloride (RHCL) from the conventional tablets can be attenuated by designing it into gastric floating drug delivery systems. The present work is aimed for the development of sustained release floating tablet of RHCL using different viscosity grade polymers. The pre-compression properties of power mixes and post-compression properties of the floating tablets were evaluated. The tablets were prepared by direct compression method using a ten-station rotary tablet compression machine at the hardness of 5 kg/cm2. The presence of different viscosity grade gel forming polymers with gas generating agents and filler modulate the in vitro buoyancy. The formulations H5, C4 and K2 were found to be optimized and can be retained in the stomach to improve peroral sustained delivery of RHCL.
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